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[title] => [Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis.]
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<tr class="odd"><td align="right"><span class="biblio-row-title">Publication Type</span></td><td> </td><td>Journal Article</td> </tr>
<tr class="even"><td align="right" valign="top" width="20%"><span class="biblio-row-title">Year of Publication</span></td><td> </td><td>2008</td> </tr>
<tr class="odd"><td align="right" valign="top" width="20%"><span class="biblio-row-title">Authors</span></td><td> </td><td><a href="/biblio/author/Barone+BB">Barone BB , Yeh HC , Snyder CF , Peairs KS , Stein KB , Derr RL , Wolff AC , Brancati FL ,</a></td> </tr>
<tr class="even"><td align="right" valign="top" width="20%"><span class="biblio-row-title">Journal Title</span></td><td> </td><td>JAMA : the journal of the American Medical Association</td> </tr>
<tr class="odd"><td align="right" valign="top" width="20%"><span class="biblio-row-title">Volume</span></td><td> </td><td>300</td> </tr>
<tr class="even"><td align="right" valign="top" width="20%"><span class="biblio-row-title">Pages</span></td><td> </td><td>2754-64</td> </tr>
<tr class="odd"><td align="right" valign="top" width="20%"><span class="biblio-row-title">Abstract</span></td><td> </td><td><p>CONTEXT: Diabetes mellitus appears to be a risk factor for some cancers, but the effect of preexisting diabetes on all-cause mortality in newly diagnosed cancer patients is less clear. OBJECTIVE: To perform a systematic review and meta-analysis comparing overall survival in cancer patients with and without preexisting diabetes. DATA SOURCES: We searched MEDLINE and EMBASE through May 15, 2008, including references of qualifying articles. STUDY SELECTION: English-language, original investigations in humans with at least 3 months of follow-up were included. Titles, abstracts, and articles were reviewed by at least 2 independent readers. Of 7858 titles identified in our original search, 48 articles met our criteria. DATA EXTRACTION: One reviewer performed a full abstraction and other reviewers verified accuracy. We contacted authors and obtained additional information for 3 articles with insufficient reported data. RESULTS: Studies reporting cumulative survival rates were summarized qualitatively. Studies reporting Cox proportional hazard ratios (HRs) or Poisson relative risks were combined in a meta-analysis. A random-effects model meta-analysis of 23 articles showed that diabetes was associated with an increased mortality HR of 1.41 (95% confidence interval [CI], 1.28-1.55) compared with normoglycemic individuals across all cancer types. Subgroup analyses by type of cancer showed increased risk for cancers of the endometrium (HR, 1.76; 95% CI, 1.34-2.31), breast (HR, 1.61; 95% CI, 1.46-1.78), and colorectum (HR, 1.32; 95% CI, 1.24-1.41). CONCLUSIONS: Patients diagnosed with cancer who have preexisting diabetes are at increased risk for long-term, all-cause mortality compared with those without diabetes.</p>
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<tr class="even"><td align="right" valign="top" width="20%"><span class="biblio-row-title">URL</span></td><td> </td><td><a href="http://jama.ama-assn.org/cgi/pmidlookup?view=long&pmid=19088353">http://jama.ama-assn.org/cgi/pmidlookup?view=long&pmid=19088353</a></td> </tr>
<tr class="odd"><td align="right" valign="top" width="20%"><span class="biblio-row-title">PubMed URL</span></td><td> </td><td><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/19088353?dopt=Abstract" title="http://www.ncbi.nlm.nih.gov/pubmed/19088353?dopt=Abstract">http://www.ncbi.nlm.nih.gov/pubmed/19088353?dopt=Abstract</a></p>
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[biblio_authors] => [<a href="/biblio/author/Barone+BB">Barone BB , Yeh HC , Snyder CF , Peairs KS , Stein KB , Derr RL , Wolff AC , Brancati FL ,</a>]
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[biblio_abst_e] => [<p>CONTEXT: Diabetes mellitus appears to be a risk factor for some cancers, but the effect of preexisting diabetes on all-cause mortality in newly diagnosed cancer patients is less clear. OBJECTIVE: To perform a systematic review and meta-analysis comparing overall survival in cancer patients with and without preexisting diabetes. DATA SOURCES: We searched MEDLINE and EMBASE through May 15, 2008, including references of qualifying articles. STUDY SELECTION: English-language, original investigations in humans with at least 3 months of follow-up were included. Titles, abstracts, and articles were reviewed by at least 2 independent readers. Of 7858 titles identified in our original search, 48 articles met our criteria. DATA EXTRACTION: One reviewer performed a full abstraction and other reviewers verified accuracy. We contacted authors and obtained additional information for 3 articles with insufficient reported data. RESULTS: Studies reporting cumulative survival rates were summarized qualitatively. Studies reporting Cox proportional hazard ratios (HRs) or Poisson relative risks were combined in a meta-analysis. A random-effects model meta-analysis of 23 articles showed that diabetes was associated with an increased mortality HR of 1.41 (95% confidence interval [CI], 1.28-1.55) compared with normoglycemic individuals across all cancer types. Subgroup analyses by type of cancer showed increased risk for cancers of the endometrium (HR, 1.76; 95% CI, 1.34-2.31), breast (HR, 1.61; 95% CI, 1.46-1.78), and colorectum (HR, 1.32; 95% CI, 1.24-1.41). CONCLUSIONS: Patients diagnosed with cancer who have preexisting diabetes are at increased risk for long-term, all-cause mortality compared with those without diabetes.</p>]
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<tr class="odd"><td align="right"><span class="biblio-row-title">Publication Type</span></td><td> </td><td>Journal Article</td> </tr>
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<tr class="odd"><td align="right" valign="top" width="20%"><span class="biblio-row-title">Authors</span></td><td> </td><td><a href="/biblio/author/Barone+BB">Barone BB , Yeh HC , Snyder CF , Peairs KS , Stein KB , Derr RL , Wolff AC , Brancati FL ,</a></td> </tr>
<tr class="even"><td align="right" valign="top" width="20%"><span class="biblio-row-title">Journal Title</span></td><td> </td><td>JAMA : the journal of the American Medical Association</td> </tr>
<tr class="odd"><td align="right" valign="top" width="20%"><span class="biblio-row-title">Volume</span></td><td> </td><td>300</td> </tr>
<tr class="even"><td align="right" valign="top" width="20%"><span class="biblio-row-title">Pages</span></td><td> </td><td>2754-64</td> </tr>
<tr class="odd"><td align="right" valign="top" width="20%"><span class="biblio-row-title">Abstract</span></td><td> </td><td><p>CONTEXT: Diabetes mellitus appears to be a risk factor for some cancers, but the effect of preexisting diabetes on all-cause mortality in newly diagnosed cancer patients is less clear. OBJECTIVE: To perform a systematic review and meta-analysis comparing overall survival in cancer patients with and without preexisting diabetes. DATA SOURCES: We searched MEDLINE and EMBASE through May 15, 2008, including references of qualifying articles. STUDY SELECTION: English-language, original investigations in humans with at least 3 months of follow-up were included. Titles, abstracts, and articles were reviewed by at least 2 independent readers. Of 7858 titles identified in our original search, 48 articles met our criteria. DATA EXTRACTION: One reviewer performed a full abstraction and other reviewers verified accuracy. We contacted authors and obtained additional information for 3 articles with insufficient reported data. RESULTS: Studies reporting cumulative survival rates were summarized qualitatively. Studies reporting Cox proportional hazard ratios (HRs) or Poisson relative risks were combined in a meta-analysis. A random-effects model meta-analysis of 23 articles showed that diabetes was associated with an increased mortality HR of 1.41 (95% confidence interval [CI], 1.28-1.55) compared with normoglycemic individuals across all cancer types. Subgroup analyses by type of cancer showed increased risk for cancers of the endometrium (HR, 1.76; 95% CI, 1.34-2.31), breast (HR, 1.61; 95% CI, 1.46-1.78), and colorectum (HR, 1.32; 95% CI, 1.24-1.41). CONCLUSIONS: Patients diagnosed with cancer who have preexisting diabetes are at increased risk for long-term, all-cause mortality compared with those without diabetes.</p>
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<tr class="even"><td align="right" valign="top" width="20%"><span class="biblio-row-title">URL</span></td><td> </td><td><a href="http://jama.ama-assn.org/cgi/pmidlookup?view=long&pmid=19088353">http://jama.ama-assn.org/cgi/pmidlookup?view=long&pmid=19088353</a></td> </tr>
<tr class="odd"><td align="right" valign="top" width="20%"><span class="biblio-row-title">PubMed URL</span></td><td> </td><td><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/19088353?dopt=Abstract" title="http://www.ncbi.nlm.nih.gov/pubmed/19088353?dopt=Abstract">http://www.ncbi.nlm.nih.gov/pubmed/19088353?dopt=Abstract</a></p>
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<tr class="odd"><td align="right"><span class="biblio-row-title">Publication Type</span></td><td> </td><td>Journal Article</td> </tr>
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<tr class="odd"><td align="right" valign="top" width="20%"><span class="biblio-row-title">Authors</span></td><td> </td><td><a href="/biblio/author/Barone+BB">Barone BB , Yeh HC , Snyder CF , Peairs KS , Stein KB , Derr RL , Wolff AC , Brancati FL ,</a></td> </tr>
<tr class="even"><td align="right" valign="top" width="20%"><span class="biblio-row-title">Journal Title</span></td><td> </td><td>JAMA : the journal of the American Medical Association</td> </tr>
<tr class="odd"><td align="right" valign="top" width="20%"><span class="biblio-row-title">Volume</span></td><td> </td><td>300</td> </tr>
<tr class="even"><td align="right" valign="top" width="20%"><span class="biblio-row-title">Pages</span></td><td> </td><td>2754-64</td> </tr>
<tr class="odd"><td align="right" valign="top" width="20%"><span class="biblio-row-title">Abstract</span></td><td> </td><td><p>CONTEXT: Diabetes mellitus appears to be a risk factor for some cancers, but the effect of preexisting diabetes on all-cause mortality in newly diagnosed cancer patients is less clear. OBJECTIVE: To perform a systematic review and meta-analysis comparing overall survival in cancer patients with and without preexisting diabetes. DATA SOURCES: We searched MEDLINE and EMBASE through May 15, 2008, including references of qualifying articles. STUDY SELECTION: English-language, original investigations in humans with at least 3 months of follow-up were included. Titles, abstracts, and articles were reviewed by at least 2 independent readers. Of 7858 titles identified in our original search, 48 articles met our criteria. DATA EXTRACTION: One reviewer performed a full abstraction and other reviewers verified accuracy. We contacted authors and obtained additional information for 3 articles with insufficient reported data. RESULTS: Studies reporting cumulative survival rates were summarized qualitatively. Studies reporting Cox proportional hazard ratios (HRs) or Poisson relative risks were combined in a meta-analysis. A random-effects model meta-analysis of 23 articles showed that diabetes was associated with an increased mortality HR of 1.41 (95% confidence interval [CI], 1.28-1.55) compared with normoglycemic individuals across all cancer types. Subgroup analyses by type of cancer showed increased risk for cancers of the endometrium (HR, 1.76; 95% CI, 1.34-2.31), breast (HR, 1.61; 95% CI, 1.46-1.78), and colorectum (HR, 1.32; 95% CI, 1.24-1.41). CONCLUSIONS: Patients diagnosed with cancer who have preexisting diabetes are at increased risk for long-term, all-cause mortality compared with those without diabetes.</p>
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